Be practical. Step into your space and pick something up. When's the last time you used it? If its been more than a year, consider the space its been utilizing for the past 365 days. Could someone else get practical use of this item? Is this item helping you live your best life? Think about it and make a decision: Keep or Toss.
If you're bringing in a new item into your space, have a designated place in mind for it to "live". Weigh the value of that item to the space it will occupy. If you cant find a place for the items you already own, are you really willing to give up MORE space for MORE things?. Focus on finding a "home" for the items in your space. If you can't, then you probably don't need it.
Junk is trash. Why would you want to dedicate a drawer in your home or office to trash? Be very specific about the contents of your drawers and closets. Break everything item down by category and organize your drawers to hold each category. Stick to those categories and organize them accordingly. Drawer dividers are a great way to organize drawers by purpose or category. Visit this drawer on cleaning day and make sure that you haven't had any "junk" creep its way back into your space.